Unknown Cause of Acute Liver Failure

Unknown Cause of Acute Liver Failure: Determination of Early Mortality Predictive Factors

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02041637

Acronym

HASIPRO

Enrollment

Registered

2014-01-22

Start date

2013-06-30

Completion date

2017-01-31

Last updated

2017-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Failure, Unknown Etiology

Keywords

liver failure, etiology, liver transplantation

Brief summary

The purpose of the study is to evaluate the outcome and to determine predictive factors of patients admitted in a context of acute liver failure without identified cause.

Detailed description

Methodology: Multicentric French national cohort with prospective collection of data and constitution of biobank, in patients hospitalized in a context of acute liver failure without known cause at admission. Follow-up during 3 months for each patients. The primary objective is to determine predictive factors of early mortality. This study is an observational cohort and patients will received standard care during the follow-up.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Acute liver failure defined by a PT\<50% or INR\>1.5; * with or without hepatic encephalopathy; * without cause identified at admission, and non A non B hepatitis; * age\>18 year old; * signed an informed consent.

Exclusion criteria

* chronic liver disease; * Patient under guardianship

Design outcomes

Primary

Measure	Time frame
mortality	At 3 months

Secondary

Measure	Time frame
Liver transplantation rate	At 3 months
Overall survival rate	At 3 months
post-transplant mortality rate	At 3 months

Countries

France

Outcome results