Prostate Cancer
Conditions
Brief summary
Robot assisted prostatectomy reduces the patients' postoperative pain and leads to rapid rehabilitation. But pneumoperitoneum affects the kidney. The increase of stress hormone reduces the glomerular filtration and the vaso-contraction of renal vessels leads the renal ischemia. Remifentanil is analgesics coupled with μ opioid receptor. In high dose of remifentanil, it is associated with κ and δ receptors, which leads to renal protection effect in animal study. Also, remifentanil infusion during anesthesia showed a diuretic effect. The purpose of this study is to investigate the remifentanil effect on renal function during robot assisted prostatectomy.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
20 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* ages \> 19 years and \< 85 years * the patients undergoing a general anesthesia for robot assisted prostatectomy
Exclusion criteria
* incomplete record * history of opioid or steroid using * solitary kidney * history of kidney transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| acute kidney injury incidence based on Acute Kidney Injury Network criteria | 24 hours after end of surgery | Acute kidney injury incidence based on Acute Kidney Injury Network criteria was defined as increase in serum creatinine from baseline of ≥ 0.3 mg/dl within a 48-hour period. Acute kidney injury is evaluated at POD 1. |
Countries
South Korea
Contacts
Primary ContactJi Eun Kim, MD
Outcome results
None listed