Meconium Aspiration Syndrome
Conditions
Keywords
Lung lavage,, Surfactant,, Duration of mechanical, ventilation
Brief summary
Meconium aspiration syndrome (MAS) is an important cause of severe respiratory failure in newborn infants. Treatment for MAS is mainly supportive but surfactant therapy might change the course of the disease. Aim of the study to evaluate whether lung lavage with dilute or bolus poractant alfa changes the duration of mechanical respiratory support or other outcomes in MAS.
Interventions
DRUGLung lavage with surfactant
DRUGBolus surfactant
Sponsors
Zekai Tahir Burak Women's Health Research and Education Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 7 Days
Healthy volunteers
No
Inclusion criteria
* Infants with a gestational age ≥ 36 weeks, birth weight ≥ 2.0 kg, evidence of passage of meconium at or before delivery, typical chest radiology findings and mechanically ventilated infants with a mean airway pressure ≥ 12 cm H2O were enrolled.
Exclusion criteria
* Congenital cardiac anomalies * Major congenital anomalies * Hemodynamically unstable infants
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of mechanical ventilation | up to 2 weeks | Total duration of mechanical ventilation, mode and ventilator parameters are noted till the baby is on mechanical ventilation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Complications | up to 4 weeks | Incidence of Persistent Pulmonary Hypertension by Echocardiography and Pneumothorax by transillumination confirmed by chest x-ray. |
| Duration of Hospital Stay | Up to 8 weeks or till discharge | We will record length of stay in a level III neonatal intensive care unit. |
| Mortality | Up to 3 months or till discharge | We will record who died until discharge. |
Countries
Turkey (Türkiye)
Outcome results
None listed