Muscle Training Induced Angiogenesis in COPD

Impact of Exercise Training on Skeletal Muscle Capillary Maturation During Angiogenesis in COPD Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02040363

Acronym

COPDµvasc

Enrollment

Registered

2014-01-20

Start date

2014-01-31

Completion date

2016-08-31

Last updated

2020-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral Muscle Dysfunction, COPD

Keywords

COPD, skeletal muscle, angiogenesis, exercise training, intensity

Brief summary

COPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients. While the muscle capillary creation in response to exercise training is blunted in COPD patients, the maturation of the neo-capillaries could also be blunted and contribute to the impaired aniogionenesis in patients. Because the capillary maturation is a sensitive and dynamic process, only different modalities of exercise training and multiple time-points of measures would allow to capture this microvascular adaptation. Aim of the study : Compare the muscle capillary maturation in response to training at 5 and 10 weeks, in sedentary healthy subject trained at the intensity of the ventilatory threshold (60-65% of VO2max), versus :- COPD patients trained at a similar intensity (60-65% of VO2max)- COPD patients trained at a similar absolute intensity (90% of VO2max).

Interventions

PROCEDUREMuscular biopsy

OTHER5-10 weeks sport training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

40 Years to 78 Years

Healthy volunteers

Yes

Inclusion criteria

* COPD patients : * FEV1\<80%pred. * non exacerbation during the past 4 weeks * no oxygen therapy, - Healthy subjects: * \<150min/week of moderate-to-vigorous physical activity, * Voorrips score \<9

Exclusion criteria

* Unstable comorbidity * Long term oxygen therapy or ventilation * Rehabilitation program during the past 12 months * nutritional supplementation during the past 4 weeks * allopurinol or N-acetylcystein during the past 4 weeks * long corticosteroid treatment during the past 6 months * hyperreactivity to xylocain * anticoagulant or platelet aggregation inhibitors treatment * participation to an other research study-pregnancy or impossibility to provide informed consent, ...

Design outcomes

Primary

Measure	Time frame
Capillary-o-fiber ratio assessed by immunochemistry on a muscle biopsy of the vastus lateralis of the quadriceps	5 weeks

Secondary

Measure	Time frame
quadriceps endurance	5 weeks
Pericyte coverage of skeletal muscles capillaries assessed by immunostaining of a muscle biopsy of the vastus lateralis of the quadriceps	5 weeks
Effect of the serum of COPD patients and SHS on pericyte morphology and in vitro	10 weeks
Effect of the serum of COPD patients and SHS on pericyte/endothelial cells interactions in vitro	10 weeks
Effect of the serum of COPD patients and SHS on pericyte/endothelial cells interactions in vivo	10 weeks

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026