Deaths
Conditions
Keywords
Pralidoxime, atropine, organophosphorous poisoning.
Brief summary
To evaluate the effectiveness of Pralidoxime, a drug used for treatment of pesticide poisoning (Organophosphorous poisonings)
Detailed description
The present study was designed to critically analyze the role of pralidoxime in patients with moderate to severe poisoning by dividing them into two comparable groups in all aspects and using WHO recommended dose of pralidoxime (30mg/kg bolus I.V over 20 min followed by 8mg/kg/hr continuous infusion). This dose and continuous infusion protocol is more likely to maintain adequate blood concentrations of pralidoxime throughout 24 hours and thus would avoid any failures in effectiveness of pralidoxime because of inconsistent blood levels.
Interventions
DRUGPralidoxime
Pralidoxime was compared to placebo to study the effects of the drug on mortatlity
Sponsors
Sheri Kashmir Institute of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
14 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
history of alleged organophosphorus intake age \> 14 years \< 60 years clinical signs and symptoms of organophosphorus poisoning.
Exclusion criteria
\< 14 years or \> 60 years of age known pregnancy pralidoxime administration at the transferring hospital carbamate poisoning any chronic illnesses ≥ 12 hour interval from time of poisoning to initiation of treatment pre-hospital cardiac or respiratory arrest.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortality rate | upto one year |
Secondary
| Measure | Time frame |
|---|---|
| duration of ventilation | upto one year |
Other
| Measure | Time frame |
|---|---|
| duration of ICU stay | upto one year |
Countries
India
Outcome results
None listed