Establishment of a Creatinine Clearance Estimation Equation and Daily Creatinine Excretion Reference Table for Taiwanese

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02040181

Enrollment

700

Registered

2014-01-20

Start date

2014-01-31

Completion date

2014-07-31

Last updated

2014-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Estimated Creatinine Clearance

Keywords

renal function, creatinine clearance

Brief summary

It's important to dose according to renal function in who has impaired kidney function. There are two common methods estimating renal function: one is creatinine clearance estimated by Cockcroft-Gault (CG) equation; another is glomerular filtration rate estimated by Modification of Diet in Renal Disease (MDRD) equation. The previous study (not published) showed that CG underestimated 24 hour measured urine creatinine clearance by our team. The difference may be due to ethnicity. Thus we want to establish a estimated creatinine clearance equation fitting in Taiwanese. Besides, there are lots of studies discussing difference between CG and MDRD. We have found that MDRD overestimated CG in patients who were older or thin. Therefore, we want to analysis which characteristics of patients the difference are largest or smallest.

Interventions

None listed

Study design

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* age above or equal to 20 year-old adults * had 24 hour urine creatinine collection

Exclusion criteria

* lack of at least one :sex, diagnosis, age,weight, height * serum creatinine beyond linear test range * with extreme weight or height * with acute kidney injury or specific diagnosis * with extremities of daily urine creatinine excretion

Design outcomes

Primary

Measure	Time frame	Description
Coefficient of determination of estimated creatinine clearance equation	3 years	Compare new estimated creatinine clearance equation for Taiwanese with Cockcroft-Gault equation

Secondary

Measure	Time frame
Differences of daily urine creatinine excretion between Caucasian and Taiwanese	3 years

Other

Measure	Time frame
In which subgroup that difference between CG and MDRD is smallest or largest	1 year

Outcome results