Machado Joseph Disease (SCA3)
Conditions
Keywords
Machado Joseph disease, Deep TMS, TMS, Transcranial Magnetic Stimulation, SCA3, Magnetic Stimulation, Brainsway
Brief summary
To test the effects of low frequency deep rTMS using the novel HCERMJD-coil on cerebellar deficits in patients with SCA3 and to establish its safety in this population. Investigator is anticipate that stimulation of the cerebellum with the novel HCERMJD-coil may induce significantly therapeutic effects in patients with SCA3 and will pave the way for establishing a novel and effective treatment for this disorder.
Interventions
DEVICEDeep TMS
1Hz Stimulation
Sponsors
Brainsway
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* SCA3 patients aged 20 - 80 years, with detectable clinical signs and confirmed genetic diagnosis.
Exclusion criteria
1. Patients who have concomitant epilepsy. 2. History of seizure or heat convulsion. 3. Patients on neuroleptics. 4. Patients with dementia (MMSE\<25) or any unstable medical disorder. 5. History or current unstable hypertension. 6. History of head injury or neurosurgical interventions. 7. History of any metal in the head (outside the mouth). 8. Known history of any metallic particles in the eye, implanted cardiac pacemaker, implanted neurostimulators, surgical clips (above the shoulder line) or any medical pumps. 9. History of frequent or severe headaches. 10. History of migraine. 11. History of hearing loss. 12. History of cochlear implants 13. History of drug abuse or alcoholism. 14. Pregnancy or not using a reliable method of birth control. 15. Participation in current clinical study or clinical study within 30 days prior to this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale for the Assessment and Rating of Ataxia (SARA) | 30 days |
Countries
Israel
Outcome results
None listed