Obesity, Binge Eating Disorder
Conditions
Keywords
Obesity, Binge eating disorder, fMRI, gut hormones
Brief summary
Binge Eating Disorder (BED) may be associated with he development of obesity. However, the pathogenesis of BED is currently unclear, thus making the development of treatment and prevention strategies for BED difficult. Differences in the mechanisms regulating food intake may go some way to reveal potential mechanisms for BED.The purpose of this study is to investigate the responses of key gut-derived hormones that are associated with the regulation of food intake and functional brain activity to food cues using fMRI in BED patients and weight matched controls.
Detailed description
Participants will attend the laboratory on two separate occasions following an overnight fast. Following baseline measures they will be provided wither with a 600mL (600kcal) liquid meal (Fed condition) or a volume matched amount of plain water (Fasted condition) to consume within 15 min in a randomized crossover design. Blood samples will be collected for during the subsequent 120min to measure the glucose, insulin and gut hormone responses, and subjective appetite ratings will be collected. 1500mg of acetaminophen will be added to each of the test drinks so that the appearance in the blood can be used as a proxy measure of gastric emptying. Participants will then undergo a 45min brain scan to assess the responses to visual and auditory food cues.
Interventions
DIETARY_SUPPLEMENTFed Condition
Subjects will consume a 600mL 600kcal liquid test meal
DIETARY_SUPPLEMENTFasted condition
Subjects will consume 600mL plain water.
PROCEDUREBlood samples
Blood samples will be collected at -15, 0, 10, 30, 60, 90, 120 min
BEHAVIORALSubjective appetite ratings
Appetite ratings will be collected at -15, 0, 10, 30, 60, 90, 120 min.
PROCEDUREfMRI scan
Blood Oxygen Dependent (BOLD) signal response to pictures and words of food and non-food items will be measured using functional magnetic resonance imaging (fMRI).
Sponsors
Columbia University
New York Obesity and Nutrition Research Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-65 years * BMI 30-50 kg/m2 * Weight stable (\<5% change in body weight during past 3 months) * Right handed
Exclusion criteria
* Smokers * Regular use of medications * Current or intended participation in a weight-loss program (diet or exercise) * Females who are pregnant or lactating
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI responses to food cues | 45 min | Blood oxygen dependent signal (BOLD) response in exposure to auditory and visual food cues will be measured during a fMRI scan and the difference between responses in the fed condition compared with those in the fasted condition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gut hormone responses | 120 min | Blood samples will be collected at -15, 0, 10, 30, 60, 90, 120 min following the ingestion of the liquid test meal and analyzed to determine the gut hormone responses. |
| Subjective appetite ratings | 120 min | Subjective ratings of appetite will be collected using a visual analogue scale (VAS) at -15, 0, 10, 30, 60, 90, 120 min following the liquid test meal |
Outcome results
None listed