Investigating the Role of EN in NTIS Among Fistula Patients

a Prospective Study to Investigate the Role of Enteral Nutrition in Nonthyroidal Illness Syndrome Among Fistula Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02038504

Acronym

EN;NTIS

Enrollment

Registered

2014-01-16

Start date

2013-01-31

Completion date

2014-04-30

Last updated

2014-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal Fistula

Keywords

gastrointestinal fistula, enteral nutrition, thyroid function

Brief summary

The purpose of this study is to investigate whether enteral nutrition are effective in the treatment of nonthyroidal illness syndrome among fistula patients.

Detailed description

Nonthyroidal illness syndrome (NTIS) is a common alterations in thyroid function observed in about 70% of hospitalized patients, with or without acute systemic illnesses. Mechanisms in the pathogenesis of NTIS are not yet well understood. Our previous study demonstrated that NTIS occurred frequently with a prevalence of 57.5% in gastrointestinal fistulas patients. In recent study, it has been shown that early enteral nutrition decreases the duration of hospitalization and mortality in the burn population, indicating a potential role of enteral nutrition in NTIS.In addition, the management of fistula patients requires bundle therapy including Nutrition therapy, especially enteral nutrition.The purpose of this study is to investigate whether enteral nutrition are effective in the treatment of nonthyroidal illness syndrome among fistula patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of gastrointestinal fistula * Clinical diagnosis of nonthyroidal illness syndrome * Using enteral nutrition for fistula management

Exclusion criteria

* patients who were prescribed drug which may affect thyroid function before or in our study * patients who were diagnosed as primary thyroid disease

Design outcomes

Primary

Measure	Time frame	Description
Thyroid function	Changes of thyroid function from baseline at 1 week,2 week, 3 week and 4 week after enrolled.	Thyroid function assessment includes level of free triiodothyronine,total triiodothyronine,free thyroxin,total thyroxin,thyroid stimulating hormone,thyroid stimulating hormone index,and standard thyroid stimulating hormone index

Countries

China

Outcome results