Acute Coronary Syndrome
Conditions
Keywords
Acute coronary syndrome, persistent platelet reactivity
Brief summary
Study of persistent platelet reactivity during acute coronary syndrome. Patients are included at admission to the hospital. Platelet aggregation is evaluated by platelet function testing after blood sampling during hospitalization. No changes in treatment is planned.
Detailed description
Blood samples are performed on day 2 and 4 and collected with usual blood samples and analyzed by the laboratory. Maximal aggregation intensity and velocity are measured by light transmission aggregometry induced by arachidonic acid (AA) or adenosine diphosphate (ADP). Platelet function analyzer will be also used. No changes in treatment in response to the results is planned.
Interventions
None listed
Sponsors
Hopital Lariboisière
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute coronary syndrome with elevation in troponin
Exclusion criteria
* anticoagulant treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| maximum aggregation intensity | day 2 | Light transmission aggregometry following exposition to arachidonic acid 0.5mg/ml during the acute phase (day2-day 5) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maximum aggregation intensity | Day 2 | Light transmission aggregometry following exposition to adenosine diphosphate during the acute phase (day2-day 5) and during the chronic phase (day 30-day 60) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Major cardiovascular and cerebrovascular events (MACCE) | one year | Major cardiovascular and cerebrovascular events : death, myocardial infarction, stroke, rehospitalisation and bleeding (academic research consortium) events at 1 year |
| microvascular resistance index | Day 1 | measurement during primary PCI on admission |
Countries
France
Outcome results
None listed