Carpal Tunnel Syndrome
Conditions
Brief summary
A prospective cohort follow-up study design is undertaken. Both males and females with mild to moderate carpal tunnel syndrome will receive standard-of-care wrist splint for 6 weeks and undergo follow up studies for data collection. Controls will also be seen for a one time visit.
Interventions
None listed
Sponsors
University of California, Davis
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years or older and; * Diagnosis of mild to moderate CTS with median motor latency at 8 cm is greater than 4.5 milliseconds or Combined Sensory Index \> 0.9 where first line therapy is indicated to include nocturnal wrist bracing * Control subjects without symptoms of carpal tunnel syndrome.
Exclusion criteria
* Evidence of severe CTS as seen with electromyographic changes in the body of the muscle * Untreated hypothyroidism, Rheumatologic disorders * Diagnosed Severe CTS or Chronic symptoms of carpal tunnel, greater than 1 year, this includes wasting of the hand muscles * Undergoing or previously treated for carpal tunnel on affected side. This includes surgery (carpal tunnel release), corticosteroid injections, bracing within the last 3 months while wearing the brace consistently every night, or any other intervention. * Currently pregnant or \< 3 months post partum * History of wrist, hand fracture or severe trauma to affected hand and/or wrist * Known tumor, mass or deformity of the hand/wrist * Inflammatory articular disease of the joints or tendons Existing cervical radiculopathy or previous surgeries to the neck for radicular symptoms * History of electrodiagnostic evidence of generalized polyneuropathy or evidence of denervation * Diagnosed neuromuscular disorders which may complicate CTS diagnosis * Implanted electronic device (pacemaker, intrathecal pump/stimulator) * Any illness that makes it unsafe for the patient to participate in the study * Not fluent in English as NeuroQOL and other subjective information is limited to the English language interpretation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cross sectional area of median nerve using ultrasound | 6 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Patient-reported outcome measures using NeuroQOL and CTSAQ | 6 weeks |
| Motor latency, motor amplitude, sensory velocity and sensory amplitude with electrodiagnostic study | 6 weeks |
| cross sectional area, electrodiagnostic study, age, gender, height, weight, BMI, wrist circumference, wrist width. smoking and handedness as predictors of improvement (or no improvement) in the NeuroQOL and CTSAQ-measured clinical severity scale. | 6 weeks |
Countries
United States
Outcome results
None listed