Parkinson's Disease
Conditions
Keywords
Parkinson's disease, Auditory Cueing
Brief summary
Parkinson's disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson's disease include the following motor tasks: difficult in initiating movement, performing rhythmic movement or serial movement, the ability of learning motor movement is also affected. The primary treatment for Parkinson's disease is medical treatment; surgery is used if in need. Rehabilitation such as physical therapy, which aims to improve patient's quality of life and functions, is a non-invasive treatment and value for PD patients. Auditory cue is a technique that widely applied on training patients with Parkinson's disease, and some researches revealed that auditory cueing could improve motor performance. However, the mechanism under this treatment technique is still unknown. This study is to investigate the effect of auditory cueing on rhythmic finger movement in patients with Parkinson's disease. To investigate the mechanism under auditory cueing, neurophysiological data such as motor cortex excitability and blood flow in cortical cortex will be obtained by using Transcranial magnetic stimulation (TMS) and near infrared spectroscopy (NIRS).
Interventions
PROCEDURErhythmic auditory stimulation
Participants perform the finger tapping at the same time give rhythmic auditory stimulation ,and need to execute tapping with auditory stimulation.
Sponsors
Chang Gung University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of Parkinson disease
Exclusion criteria
* Clinical diagnosis of other neurological diseases * Dementia * Been diagnosed with any mental illness * History of seizures * Brain trauma * Body with a pacemaker or other electrical stimulator * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Finger Tapping | Baseline,45-60 minutes. | Record pre-test and post-test change. |
| Motor evoked potential | Baseline,45-60 minute | Use single-pulse TMS to assess Motor evoked potential change. |
| Intracortical inhibition & Intracortical facilitation | Baseline,45-60 minutes | Use paired-pulse TMS to record pre-test and post-test change. |
| Blood oxygen dependent level | Baseline, in experiment,45-60 minutes | Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change. |
Countries
Taiwan
Outcome results
None listed