Acute Coronary Syndrome, Acute Myocardial Infarction, Unstable Angina (Intermediate Coronary Syndrome)
Conditions
Keywords
Ticagrelor, strut coverage, DES, ACS, OCT
Brief summary
The investigators hypothesized that ticagrelor may enhance endothelial healing after DES implantation by increasing adenosine concentrations by the inhibition of adenosine uptake into erythrocytes, compared to clopidogrel. Thus, the investigators will evaluate the extent of endothelialization (stent strut coverage) and neointimal hyperplasia (neointimal thickness) 3 months after DES implantation by optical coherence tomography (OCT)
Interventions
DRUGTicagrelor
Ticagrelor - 180 mg loading and 90 mg bid maintenance for 3 months
DRUGClopidogrel
Clopidogrel - 600 mg loading and 75 mg qd maintenance for 3 months
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients ≥ 20 years old * Patients who are hospitalized and expected to undergo PCI for acute coronary syndrome, including acute myocardial infarction and unstable angina.
Exclusion criteria
* Age \> 80 years * Cardiogenic shock or unstable patients * Increased risk of bleeding, anemia, thrombocytopenia * A need for oral anticoagulation therapy * Pregnant women or women with potential childbearing * Life expectancy \< 1 year
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stent re-endothelialization | Three months after stent implantation | Percentage of stent coverage measured by OCT |
| Neointimal hyperplasia | Three months after stent implantation | Neointimal thickness measured by OCT |
Countries
South Korea
Outcome results
None listed