Penicillin Allergy
Conditions
Brief summary
The proposed research project will retrospectively review the anesthetic records over the past 5 years and identify patients who present with a history of penicillin allergy or allergy to an antibiotic in the penicillin family. The reason for that history and the facts on which that allergy are noted will be determined. Additionally, the choice of antibiotic prophylaxis will be recorded and any adverse effect to that antibiotic noted. We will also note whether appropriate timing of the antibiotic is achieved.
Interventions
DRUGAntibiotic
Sponsors
Joseph D. Tobias
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients that are labeled as penicillin or penicillin family allergic.
Exclusion criteria
* As neurosurgical patients routinely receive vancomycin at NCH for surgical prophylaxis, they will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Subjects With Antibiotic Related Adverse Event | 24 hours |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Penicillin Allergy Antibiotic | 513 |
| Total | 513 |
Baseline characteristics
| Characteristic | Penicillin Allergy |
|---|---|
| Age, Categorical <=18 years | 513 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 0 Participants |
| Region of Enrollment United States | 513 participants |
| Sex: Female, Male Female | 250 Participants |
| Sex: Female, Male Male | 263 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 12 / 513 |
| serious Total, serious adverse events | 0 / 513 |
Outcome results
Primary
Number of Subjects With Antibiotic Related Adverse Event
Time frame: 24 hours
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Penicillin Allergy | Number of Subjects With Antibiotic Related Adverse Event | 12 participants |