Hypertriglyceridemia
Conditions
Keywords
Fish oils, Triglycerides, Blood pressure
Brief summary
This is a trial of two marketed fish oil supplements, one with a high EPA:DHA ratio and the other with a high DHA:EPA ratio, to examine differential effects on platelet function, blood pressure, and fasting triglyceride levels.
Detailed description
Observational studies have shown that fish consumption is associated with a lower risk of cardiovascular disease, and clinical trials have demonstrated that fish oil nutritional supplementation is associated with improvement in cardiometabolic risk factor profiles including fasting triglycerides and blood pressure. However, the mechanisms of action of fish oils are not well understood. Specifically, the effects of different compositions in terms of the ratio of the fatty acids EPA and DHA are not known. We are proposing a pilot and feasibility study of fish oil nutritional supplementation in 40 healthy adult participants with two different commercially available fish oil (high EPA/DHA ratio, high DHA/EPA ratio, sample of 20 per group) with the hypothesis that 4 weeks of supplementation with fish oil results in differential changes in platelet function, blood pressure and fasting triglyceride levels . We will also bank blood and urine for future mechanistic studies. This pilot study will allow us to collect preliminary data for definitive mechanistic studies of the effects of fish oil supplementation and to demonstrate the feasibility of this protocol.
Interventions
DIETARY_SUPPLEMENTDHA-enriched
DHA 3g + 600 mg EPA in 6 g of fish oil/day given for 4 weeks
DIETARY_SUPPLEMENTEPA-enriched
EPA 2.4 g + DHA 600mg in 6 g of fish oil/day for 4 weeks
Sponsors
Johns Hopkins University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults 20-75 years of age. * Participant of the Principal Investigator's prior studies studies who have agreed to be contacted for future studies.
Exclusion criteria
* Current user of fish oil supplements * Current user of statins * Allergy to fish or seafood products * Diagnosed/treated diabetes mellitus * Using aspirin or NSAIDS or other blood-thinning medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fasting triglyceride level | 4 weeks | Fasting serum triglyceride levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Seated blood pressure | 4 weeks | Seated blood pressure |
Countries
United States
Outcome results
None listed