Squamous Cell Carcinoma of Hypopharynx, Squamous Cell Carcinoma of Larynx, Squamous Cell Carcinoma of Oropharynx
Conditions
Keywords
NBI,, squamous cell carcinoma,, pharynx, larynx, surgical margins.
Brief summary
The aim of this study is to prospectively determine if the use of NBI endoscopy modifies the superficial extension of these tumors.
Detailed description
Several studies have already showed the interest of the use of NBI for the early diagnosis of malignancies of the upper aerodigestive tract. For all tumors, the most accurate evaluation of its limits is very important to perform the best strategy of treatment. If surgery seems to be the best option, surgical margins must be widely healthy. Despite the systematic transnasal flexible endoscopy with white lamp followed by laryngoscopy under general anesthesia (LGA) and tomodensitometric evaluation, surgical margins can be unhealthy (in situ carcinoma or dysplasia). We propose to evaluate if the use of the NBI could be useful to determine the superficial spread of squamous cell carcinomas in these locations. To April 2013 to Mars 2015, all patients with a suspicion of squamous cell carcinoma of the oropharynx, hypopharynx or larynx and whom a LGA are expected, are included. The day before the LGA, two endoscopies by two different physicians were performed for each patients and recorded: the first one with white light and the second one with NBI. All results are noted on a schema. Superficial extension or synchronous lesions showed by NBI are analysed and compared with with lamp technic. After surgery, surgical margins were evaluated and healthy margins were measured.
Interventions
PROCEDUREWL and NBI
For each patient with a suspicion of squamous cell carcinoma of the oropharynx, hypopharynx or larynx for whom a laryngoscopy under general anesthesia (LGA) is expected benefit the day before a transnasal endoscopy with white lamp (WL) and NBI by two different operators. Suspected mucosal abnormalities showed by one or the two technics are reported in a table wich describes the different areas of the pharynx and the larynx. During the LGA, several biopsies are performed and identified (WL and/or NBI).
Sponsors
University Hospital, Toulouse
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Patients who can benefit a laryngoscopic exam under general anesthesia
Exclusion criteria
* General anesthesia contra-indications * Local anesthesia allergy * Breast-feeding period or pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients for whom superficial extension of the tumors has been increased by NBI. | 4 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Contribution of the NBI in the diagnosis of pre-neoplastic lesions. | 4 minutes |
| Contribution of the NBI in the evaluation of surgical margins. | 4 minutes |
| Number of tumors upstaged. | 4 minutes |
| Contribution of the NBI in the diagnosis of other synchronous locations. | 4 minutes |
Countries
France
Outcome results
None listed