Predictability of Gestational Diabetes Mellitus in First and Second Trimester

Conditions

Gestational Diabetes Mellitus, Pregnancy

Keywords

Oral Glucose Tolerance Test, Fibronectin, Adiponectin, Copeptin, Cortisol

Brief summary

The objective of the study is, if an early oral glucose tolerance test combined with maternal history, condition and multiple biomarker analysis can be used to detect gestational diabetes mellitus in the first trimester (12-14 weeks of gestation).

Detailed description

It is the investigators' aim to prospectively examine an extended form of the current 1st trimester screening test for the detection of foetal aneuploidy, in order to ascertain whether this can also be used for the detection of patients at-risk for gestational diabetes mellitus. For this purpose the investigators will include a combination of new markers in a multiplex bio-array manner in conjunction with an early oral glucose tolerance test. A nested case-control proteomic analysis will be performed in a retrospective manner at the completion of this study in order to develop more specific biomarker panels. The primary outcome will be development of gestational diabetes mellitus in the second or third trimester. The secondary endpoints are the delivery outcome, neonatal morbidity, neonatal mortality, maternal morbidity and costs.

Huhn EA, Kotzaeridi G, Fischer T, Todesco Bernasconi M, Richter AS, Kunze M, Dölzlmüller E, Jaksch-Bogensperger H, Weidinger L, Eppel D, Ochsenbein-Koelble N, Bäz E, Winzeler B, Tura A, Stach H, Schäfer G, van Breda SV, Vokálová L, Hoesli I, Göbl CS.

2025-08-161 citations

10.1007/s00125-025-06517-0

Sensitivity, specificity, and diagnostic accuracy of WHO 2013 criteria for diagnosis of gestational diabetes mellitus in low risk early pregnancies: international, prospective, multicentre cohort study

Evelyn A. Huhn, Christian Göbl, Thorsten Fischer, Monya Todesco Bernasconi, Martina Kreft et al. (17 authors)

BMJ Medicine2023-09-0112 citations

10.1136/bmjmed-2022-000330

Screening of gestational diabetes mellitus in early pregnancy by oral glucose tolerance test and glycosylated fibronectin: study protocol for an international, prospective, multicentre cohort trial

Evelyn A. Huhn, Thorsten Fischer, Christian Göbl, M Todesco Bernasconi, Martina Kreft et al. (17 authors)

BMJ Open2016-10-0128 citations

10.1136/bmjopen-2016-012115

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy singleton pregnancies * Women at least 18 years old and not under guardianship

Exclusion criteria

* Maternal diseases like hypertension, diabetes mellitus and chronic disease, known infection like hepatitis or human immunodeficiency virus * Maternal history of hypertensive diseases in previous pregnancy and now under prophylactic acetylsalicylate treatment * Foetal genetic, chromosomal or intervention-requiring morphologic abnormalities

Design outcomes

Primary

Measure	Time frame	Description
Development of Gestational Diabetes in second/third trimester	24-28 weeks of gestation	Development of gestational diabetes in 24-28 weeks of gestation by pathological values in oral glucose tolerance test 75g

Countries

Switzerland

Outcome results