Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy

Pilot Study of Cough Peak Flow And Airway Clearance in Pediatric Patients With Neuromuscular Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02034305

Enrollment

Registered

2014-01-13

Start date

2014-01-31

Completion date

2021-01-01

Last updated

2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Duchenne Muscular Dystrophy

Keywords

Airway Clearance, Duchenne Muscular Dystrophy, Peak Cough Flow

Brief summary

This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP ,SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

MALE

Age

6 Years to 21 Years

Healthy volunteers

Inclusion criteria

* Age 6-21; able to cooperate with study procedures * Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy

Exclusion criteria

* Need for mechanical ventilation during the day * Recent (within 2 weeks) lower respiratory tract infection

Design outcomes

Primary

Measure	Time frame
Spontaneous cough clearance	Assessed at multiple time points over 30 minutes

Countries

United States

Outcome results