Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis?

Secretion of Neutrophil Gelatinase Associated Lipocalin in Septic Patients and the Development of Acute Kidney Injury

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02034240

Enrollment

Registered

2014-01-13

Start date

2014-01-31

Completion date

2015-04-30

Last updated

2015-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Septic Shock, Severe Sepsis

Brief summary

Patients with severe infection and sepsis are in high risk of hypo perfusion and therefore organ affection. Temporary or permanent kidney failure is a common complication in these patients. Today's golden standard for kidney failure detection is creatinine levels rising and / or oliguria. The investigators hypothesize that an even more sensitive biomarker; neutrophil gelatinase associated lipocalin(NGAL) in urine can predict kidney injury before creatinine levels rise. In recent studies NGAL in urine seem to be a sensitive biomarker in these patient to predict kidney injury, but the time factor for sampling optimally is not known. In this pilot study the investigators sample the urine at admission within the first hour of hospitalization to investigate if NGAL can be used as a predictor in an emergency setting.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Severe sepsis * Septic shock * Patients must not be able to give consent

Exclusion criteria

* Underaged (18 years ) * known kidney injury * Fully alert patients that can give consent

Design outcomes

Primary

Measure	Time frame
Development of Acute Kidney Failure	During hospitalization, anticipated approximately 5 weeks

Secondary

Measure	Time frame
Levels of NGAL in patients with kidney failure compared to creatinine	During hospitalization, anticipated approximately 5 weeks

Countries

Denmark

Outcome results