CVP and SVV During Living Donor Hepatectomy, Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)
Conditions
Keywords
liver donor, hepatectomy, vasodilator, central venous pressure, stroke volume variation
Brief summary
Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This procedure is conventionally guided by monitoring the central venous pressure (CVP). Stroke volume variation (SVV) is a novel method to substitute with CVP to monitor cardiac preload. The investigators try to evaluate the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia (validation study). Then, feasibility of vasodilator induced hypovolemia using the SVV calculated from the validation study will be tested (feasibility study).
Detailed description
This is a 2-phases study. first phase validation study : Evaluation of the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia second phase feasibility study : Comparison of the surgical field grade between validation study group(CVP guided group) and feasibility study group(SVV guided group)
Interventions
PROCEDUREvasodilator induced hypovolemia
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* adult (20-60 yr) * elective living liver donors
Exclusion criteria
* not obtained informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| target value of SVV | during living donor hepatectomy | Target value of SVV is calculated from the linear regression equation that was calculated from scatter plot made with CVP and SVV values during CVP-guided vasodilator induced hypovolemia (validation study). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| surgical field | during living donor hepatectomy | \<4 point scale\> Grade l: Very lax IVC and hepatic veins, minimal bleeding at resection plane, very easy to operate Grade ll: Lax IVC and hepatic veins, a little bleeding at resection plane, easy to operate Grade lll: Tense IVC and hepatic veins, appreciable bleeding at resection plane, somewhat difficult to operate Grade lV: Very tense IVC and hepatic veins, profuse bleeding at resection plane, very difficult to operate |
| use of inotropics | during living donor hepatectomy | — |
| estimated blood loss | during living donor hepatectomy | — |
Countries
South Korea
Outcome results
None listed