Chronic Kidney Failure, Prostatic Hyperplasia
Conditions
Keywords
Urodynamics, Glomerular Filtration Rate
Brief summary
The purpose of this study is to determine whether medical treatment for bladder outlet obstruction is effective in improvement of glomerular filtration rate and/or proteinuria.
Detailed description
Urodynamic parameters including maximal flow rate, compliance (infused volume gradient divided by bladder pressure gradient during cystometry), maximal detrusor pressure, bladder outlet obstruction index and Schäfer grade will be checked. Estimated glomerular filtration rate and urinary protein to creatinine ratio will be checked. International prostate symptom score will be checked.
Interventions
DRUGTamsulosin
Once Daily 0.2mg per oral for 6 months
Sponsors
The Catholic University of Korea
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Men with low urinary tract symptoms aged between 40 and 80 * Estimated glomerular filtration rate \< 60 or evidence of proteinuria * Bladder outlet obstruction index \> 40, Schäfer grade 2 or more, maximal flow rate lower than 10 cc/s or postvoid residual urine \> 100cc
Exclusion criteria
* Bladder outlet obstruction index less than 40, Schäfer grade 0 or 1, maximal flow rate higher than 10 ml/s and postvoid residual urine less than 100cc * Want surgical procedure * Evidence of prostate cancer or bladder cancer * Major depressive disorder, Dementia, Parkinson's disease or neurological deficits * History of pelvic irradiation * Uncontrolled diabetes mellitus or hypertension * Symptomatic orthostatic hypotension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Compliance | 6 months | This parameter can be obtained from urodynamic study. |
| Maximal detrusor pressure | 6 months | This parameter can be obtained from urodynamic study. |
| Bladder outlet obstruction index | 6 months | This parameter can be obtained from urodynamic study. |
| schäfer grade | 6 months | This parameter can be obtained from urodynamic study. |
| Maximal flow rate | 6 months | This parameter can be obtained from urodynamic study. |
Secondary
| Measure | Time frame |
|---|---|
| Estimated glomerular filtration rate | 6 months |
| Urinary protein to creatinine ratio | 6 months |
Other
| Measure | Time frame |
|---|---|
| International prostate symptom score | 6 months |
Countries
South Korea
Contacts
Primary ContactSeung-Ju Lee, MD, PhD
Backup ContactDong Sup Lee, MD, PhD
Outcome results
None listed