Prostatic Hyperplasia
Conditions
Keywords
Prostatic hyperplasia
Brief summary
Holmium laser prostatectomy will enhance voiding function. Holmium laser prostatectomy will enhance sleep quality. Holmium laser prostatectomy will enhance renal function. Holmium laser prostatectomy will enhance erectile function. Holmium laser prostatectomy will enhance the health-related quality of life.
Detailed description
Check urodynamic parameters for voiding function evaluation Check low urinary tract symptoms (IPSS: international prostate symptom score) for voiding function evaluation Check Pittsburgh Sleep Quality Index for sleep quality evaluation Check estimated glomerular filtration rate and urine protein/creatinine ratio for renal function evaluation Check International Index of Erectile Function score (IIEF-5) for erectile function evaluation Check nocturnal penile tumescence parameters for erectile function evaluation Check 36-Item Short- Form Health Survey (SF-36) for evaluation of the health-related quality of life.
Interventions
None listed
Sponsors
The Catholic University of Korea
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Prostate size over 30 cc by transrectal ultrasonography * prostate-specific antigen level less than 10 ng/ml * International prostate symptom score more than 7 * At least one of followings: Bladder outlet obstruction index \> 40, maximal flow rate \< 10 cc/sec, postvoid residual urine \>100cc or schäfer grade II or more
Exclusion criteria
* Patients who do not want surgery * Evidence of prostate cancer or bladder cancer during evaluation or treatment * All of followings: Bladder outlet obstruction index is less than 40, maximal flow rate is 10 or more cc/sec, postvoid residual urine is less than 100cc and schäfer grade II or less * Major depressive disorder, Dementia, Parkinson's disease, Neurological deficits * History of pelvic radiation therapy * Poorly controlled diabetes mellitus or hypertension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal flow rate | 3 months | This parameter can be obtained from urodynamic study. |
| Compliance | 3 months | This parameter can be obtained from urodynamic study. |
| schäfer grade | 3 months | This parameter can be obtained from urodynamic study. |
| Bladder outlet obstruction index | 3 months | This parameter can be obtained from urodynamic study. |
| Maximal detrusor pressure | 3 months | This parameter can be obtained from urodynamic study. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maximal detrusor pressure | 12 months | This parameter can be obtained from urodynamic study. |
| Maximal flow rate | 12 months | This parameter can be obtained from urodynamic study. |
| Bladder outlet obstruction index | 12 months | This parameter can be obtained from urodynamic study. |
| schäfer grade | 12 months | This parameter can be obtained from urodynamic study. |
| Compliance | 12 months | This parameter can be obtained from urodynamic study. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Estimated glomerular filtration rate | 3 months | — |
| normalized rigidity activity unit in penile base | 3 months | This parameter can be obtained from nocturnal penile tumescence test. |
| normalized rigidity activity unit in penile tip | 3 months | This parameter can be obtained from nocturnal penile tumescence test. |
| International prostate symptom score | 3 months | — |
| Pittsburgh Sleep Quality Index | 3 months | — |
| Health-related quality of life, short form 36 score | 3 months | — |
| Urinary protein to creatinine ratio | 3 months | — |
| international index of erectile function | 3 months | — |
Countries
South Korea
Contacts
Primary ContactSeung-Ju Lee, MD, PhD
Backup ContactDong Sup Lee, MD, PhD
Outcome results
None listed