Assessment of Bioavailability of Phenolics From an Orange Peel Extract

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02033330

Enrollment

Registered

2014-01-10

Start date

2013-07-31

Completion date

2014-01-31

Last updated

2014-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Improving Bioavailability

Keywords

phenolics, orange peel, bioavailability

Brief summary

In this study, the bioavailability of a specific orange peel extract is tested. The composition and morphology of the test product is altered compared to the generic product, which is used as a control. Due to intellectual property issues, more information cannot be given at this moment. Also the difference in bioavailability between a capsule and a lozenge is tested. The hypothesis is that the bioavailability of the altered extract will be improved compared to the control.

Interventions

DIETARY_SUPPLEMENTphenolics form orange peel

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy adults * BMI 18.5 to 25

Exclusion criteria

* pregnancy * smoking * alcohol or drug abuse * use of medication * use of nutritional supplements * abnormal liver or kidney function

Design outcomes

Primary

Measure	Time frame
plasma concentrations of specific phenolics and their metabolites	up to 24 hours

Secondary

Measure	Time frame
urine concentrations of specific phenolics and their metabolites	24 hours

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026