Ventilator Associated Pneumonia
Conditions
Keywords
ventilator associated pneumonia, subglottic secretion drainage, manual air-impingement operation, prolonged intubation
Brief summary
This is a randomized controlled trial compared two methods to drainage subglottic secretion in prolonged intubated patients.After enrolled, patients are randomized assigned to intermittent subglottic secretion drainage group and air-impingement manipulation group.
Detailed description
Ventilator-associated pneumonia (VAP) is the most frequent infection occurring in patients who are admitted to the ICU. The accumulation of respiratory secretions in the subglottic space is a well-proven cause of VAP. Therefore, prevention should include the aspiration of secretions from the subglottic space. Investigators invented a manual method with high-flow air produced by resuscitator to impinge secretion from the subglottic space to oral cavity. This method has been granted as a patent by Chinese national intellectual property patent office, it has been used in investigators' daily work for more than 10 years and more than 20 Chinese ICUs have used it everyday. Investigators want to compare it with conventional method which uses a special intubation tube with an independent dorsal lumen to suction subglottic secretion.
Interventions
PROCEDUREManual air-impingement operation
A method which we invented to clear subglottic secretion
The conventional method with a special tube to drainage subglottic secretion
Sponsors
Beijing Chao Yang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Should meet all the criteria: 1. Intubation less than 24 hours before admitting respiratory intensive care unit; 2. Anticipated intubation for more than 72 hours; 3. Anticipated survival time is more than 2 weeks
Exclusion criteria
Meet any of these criteria: 1. PEEP≥10cmH2O or FiO2≥0.8; 2. unstable hemodynamics; 3. severe bulla and pneumothorax; 4. enrolled in other study; 5. cuff leak test is positive.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of participants with ventilator-associated pneumonia | Up to 28 days |
Secondary
| Measure | Time frame |
|---|---|
| ICU mortality | Participants will be followed for the duration of ICU stay, an expected average of 4 weeks |
Other
| Measure | Time frame |
|---|---|
| Invasive ventilation duration | Participants will be followed for the duration of invasive ventilation, an expected average of 7-10 days |
Countries
China
Contacts
Primary ContactJie Li, Master
Backup ContactSun Bing
Outcome results
None listed