Infertility
Conditions
Keywords
Sperm DNA damage ejaculated spermatozoa Ginger Herbal Drug Herbal medicine
Brief summary
This study is a randomized, double blind, controlled clinical trials assess the efficacy of the ginger oral treatment on sperm DNA fragmentation, sperm parameters and male hormones.
Detailed description
Sperm DNA fragmentation is known to affect male fertility. Previous findings have suggested the implication of oxidative stress in the etiology of this pathological condition. The present study was designed to find out DNA fragmentation in ejaculated spermatozoa can be reduced by oral treatment with Ginger extract. 71 men with unexplained or Idiopathic infertility were randomized between a Ginger treatment (500 milligram daily for 3months) group and a placebo group. Sperm DNA fragmentation was evaluated by Terminal deoxyribonucleotidyltransferase-mediated dUTP nick-end labeling assay (TUNEL) before and after treatment. No differences in basic sperm parameters were found between the Ginger treatment and the placebo group before or after treatment. However, the percentage of DNA-fragmented spermatozoa was markedly reduced (P\< .005) in the Ginger treatment group after the treatment as compared with the pretreatment values). No difference in the pretreatment and post treatment incidence of sperm DNA fragmentation was observed in the placebo group. These data show that sperm DNA damage can be efficiently treated with oral Ginger extract administered during a relatively short time period.
Interventions
DRUGoral administration of ginger
Oral administration of ginger in patients with infertility.
DRUGPlacebo
Sponsors
Royan Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* men with idiopathic infertility or unexplained
Exclusion criteria
* history of varicocele, genitourinary inflammation or infection * history of cigarette smoking.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sperm DNA fragmentation | 3 months | Evaluation the percent of the reduction of sperm DNA fragmentation 3 months after ginger administration. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| male hormones | 3months | Evaluation the effect of ginger on male hormones 3 months after oral administration. |
| sperm count | 3 months | Evaluation the ginger on sperm count 3 months after oral administration. |
| sperm motility | 3 months | Evaluation the effect of ginger on sperm motility 3 months after oral administration. |
Countries
Iran
Outcome results
None listed