Cancer Survivor, Pediatric Cancer
Conditions
Keywords
Cancer survivors, Long-term cancer survivor
Brief summary
Survivors of childhood cancer have an increased risk of death from cardiovascular disease due to both the therapies they received while undergoing treatment and diet and lifestyle factors. The nature of cardiovascular risk and the interaction between treatment affects and cardiovascular risk factors is unknown. We propose to study vascular inflammatory markers as well as measure of blood vessel stiffness (both of which are predictive of early heart disease) in 100 pediatric cancer survivors and 100 control children. Characterization of vascular inflammation and stiffness in long-term survivors will allow for the development of future interventions to decrease inflammation through both pharmacologic and lifestyle modifications.
Interventions
PROCEDUREBlood specimen
PROCEDUREEchocardiography
Sponsors
University of Miami
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* 6-30 years of age * 2 years from the completion of therapy for cancer * free of active disease
Exclusion criteria
* \<6 or \> 30 years of age * current cancer treatment or inside of 2 years post treatment * Active disease/infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular Inflammation | single time point at initial visit | All study procedures to assess vascular inflammation will be assessed through specimen sample collection and through procedures such as (echocardiograph) |
Countries
United States
Outcome results
None listed