Prospective Cohort Study of Association of Insulin Resistance/Steatosis With Hepatic Fibrosis in CHB and NAFLD

Association Between Insulin Resistance and Hepatic Fibrosis in Combined Chronic Hepatitis B and Non-alcoholic Fatty Liver Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02031913

Enrollment

500

Registered

2014-01-09

Start date

2013-01-31

Completion date

2022-12-31

Last updated

2023-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Hepatitis B, Fatty Liver, Hepatic Fibrosis

Keywords

Chronic hepatitis B, Hepatic fibrosis, Steatosis

Brief summary

Hepatic steatosis and insulin resistance are associated with severity of fibrosis in non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, clinical significance of steatosis and insulin resistance on fibrosis in chronic hepatitis B (CHB) is not well established. The aim was to investigate the relationship between insulin resistance, hepatic steatosis, and fibrosis in patients with CHB.

Detailed description

acoustic radiation force impulse elastography

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Chronic hepatitis B patients * With evidences of hepatic steatosis on ultrasonography or pathology

Exclusion criteria

* significant alcohol consumption or other known liver diseases

Design outcomes

Primary

Measure	Time frame	Description
Insulin resistance and fibrosis indices	one year	Measurement for insulin resistance and fibrosis index for hepatic fibrosis assessment

Countries

South Korea

Outcome results