Brain Function Predictors And Outcome Of Weight Loss And Weight Loss Maintenance

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02031848

Enrollment

137

Registered

2014-01-09

Start date

2008-09-30

Completion date

2012-02-29

Last updated

2014-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

weight loss, diet

Brief summary

By doing this study, researchers hope to learn whether a person's motivation for food is different after he or she loses weight, and if imaging techniques such as fMRI can be used to predict whether the person will maintain that weight loss over time.

Interventions

OTHERDiet Intervention

OTHERAssessments and Diet Intake

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI equal to or greater than 30 kg/m2 or 18 to 24.9 * declaration they do not have plans to move out of the Greater Kansas City area for at least 1 year * willingness to be randomized * Individuals undergoing weight loss will have to present written approval from a licensed physician that they are healthy enough to participate in a program of moderate diet restriction and moderate physical activity.

Exclusion criteria

* Participation in a research project involving weight loss or PA in the previous 6 months, as these proximal experiences may impact the results of this study. * Subjects who smoke * Subjects who use special diets (i.e. vegetarian, Adkins, etc.), use medications that affect metabolism (i.e. thyroid, beta blockers), use medications that affect appetite (i.e. Meridia) or cannot exercise (i.e. walk). * Exhibit signs of eating disorders, restraint, depression * Participant has any metabolic disease that would affect energy balance (e.g. diabetes mellitus or hypothyroidism). * Individuals who report being pregnant during the previous 6 months, are lactating, or planned pregnancy within 12 months * Individuals who are not weight stable (± 4.5kg) within the previous 3 months or have more than 500 kcal/wk of planned physical activity * Serious medical risk such as type 1 diabetes, cancer, recent cardiac event (i.e. heart attack, angioplasty, etc.)

Design outcomes

Primary

Measure	Time frame	Description
Differences in brain activation to visual food cues	Change from Baseline to 3 Months	differences will be measured by scanning subjects with fMRI and measuring changes in different regions of the brain.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026