Heart Failure
Conditions
Keywords
Lysine Chloride
Brief summary
The purpose of this study is to determine if administration of supplemental chloride in the form of lysine chloride to patients with congestive heart failure will affect their neurohormonal profile as well as response to diuretics.
Detailed description
This prospective pilot pre-post study was designed to determine if supplementation of sodium free chloride ion as a lysine chloride to patients with heart failure could improve parameters of neurohormonal status and diuretic responsiveness. Volunteers will receive Lysine Chloride 7 grams three times daily for three days. At baseline and then again post lysine chloride patients will undergo sampling of venous blood for determination of neurohormonal parameters in addition to formal diuretic responsiveness testing.
Interventions
DIETARY_SUPPLEMENTLysine Chloride
Administration of 21g of lysine chloride (7g three times daily) for a period of time of 3 days
Sponsors
Yale University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years * Fluency in English * Heart failure requiring loop diuretic therapy * Loop diuretic dose ≥ 80mg/day furosemide equivalents * Stable volume status and diuretic requirement as assessed by treating physician
Exclusion criteria
* Unstable heart failure * renal replacement therapy or an estimated GFR \< 30 ml/min/1.73m2 * Significant bladder dysfunction * History of hepatic failure * Pregnancy * History of hyperinsulinemia/hyperlysinuria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in plasma renin activity following lysine chloride administration | 3 days | — |
| Change in urinary renin level following lysine chloride administration | 3 days | — |
| Change in diuretic response following lysine chloride administration | 3 days | Diuretic response will me evaluated by measuring volume of urine produced following diuretic administration |
Countries
United States
Outcome results
None listed