Peripheral Insulin Uptake in Type 2 Diabetes Mellitus and in Non-Diabetic Individuals

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02031341

Acronym

PEAKS

Enrollment

100

Registered

2014-01-09

Start date

2014-01-31

Completion date

2014-12-31

Last updated

2015-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus

Brief summary

Impaired uptake of glucose by skeletal muscle is a key feature of type 2 diabetes mellitus. It is unclear to what extent impaired insulin uptake from capillaries into skeletal muscle interstitium plays a role in this process. We hypothesize that impaired uptake of insulin from capillaries into skeletal muscle interstitium is involved in impaired glucose uptake by skeletal muscle in type 2 diabetes mellitus.

Interventions

None listed

Study design

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

30 Years to 80 Years

Healthy volunteers

Inclusion criteria

for all participants: * written informed consent * hemodynamically stable with a systolic blood pressure \> 100 mmHg * medical need to undergo a CAG procedure as determined by cardiologist

Exclusion criteria

for all participants: * ongoing myocardial infarction as determined from elevated cardiac markers * participation in an investigational trial within 90 days prior to present study * donation of blood (\> 100 mL) within 90 days prior to present study * serious mental impairment or language problems i.e. preventing to understand the study protocol/aim * Use or recent use (within 3 months of study participation) of oral glucocorticoids Inclusion criteria for non-diabetic individuals: * 30 years ≤ age ≤ 80 years (extremes included) * fasting glucose level of \< 7.0 mmol/L and HbA1C \< 6.5% (= \< 48 mmol/mol)

Design outcomes

Primary

Measure	Time frame	Description
Fore-arm insulin uptake measured as ([A]-[V]) x F in pmol/min where A = arterial insulin concentrations, V= venous insulin concentrations, F = fore arm plasma flow;	Baseline	During a single measure (thus cross-sectional) the primary endpoint will be measured.

Countries

Netherlands

Outcome results