Drug Hypersensitivity
Conditions
Brief summary
The aim of this study is (1) to assess the incidence of suspected drug allergies in a pediatric hospital and the proportion in which these reactions are confirmed to be allergic; (2) to evaluate the diagnostic values of the different allergy tests available; (3) to investigate the pathophysiology of drug allergies, particularly by investigating the role of viruses, and by performing HLA typing and a gene expression profile both in the acute phase of the reaction and 2 months later.
Interventions
None listed
Sponsors
University Hospital, Geneva
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* Participation will be proposed to any children (0 to 16 years) receiving one or several drug(s) and developing one of the following clinical manifestations: urticaria, maculopapular rash, bullous eruption, flush, anaphylaxis, serum sickness-like disease, SJS, TEN, DRESS or fever linked to drug intake.
Exclusion criteria
* Patients will be excluded if the symptoms occur more than 72 hours after any treatment was stopped or if the symptoms are clearly linked to another cause (measles, rubeola, roseola, varicella, fifth disease, Gianotti-Crosti syndrome, scarlet fever, Gibert's pityriasis or food allergy).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of suspected drug allergies in a pediatric hospital and the proportion in which these reactions are confirmed to be allergic | 3 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the diagnostic values of the different allergy tests available | 3 years | Sensitivity, specificity, negative and positive predictive value |
| Determination of the role of viruses, HLA typing and gene expression profile both in the acute phase of the reaction and 2 months later | 3 years | — |
Countries
Switzerland
Outcome results
None listed