Liver Resection
Conditions
Brief summary
This observational study will measure resting energy expenditure in patients who have undergone liver resection and compare methods of measuring resting energy expenditure.
Detailed description
Penetrating liver injury occurs commonly in victims of battlefield trauma. It is associated with a high mortality and morbidity rate. Management of liver injury is complex and challenging and can often involve debridement or anatomical resection of liver tissue. Following liver resection, the liver regenerates to its original volume. Liver regeneration involves complex metabolic processes and maximal regeneration occurs over the first post operative week. This process is highly energy dependent and adds a further burden on post operative energy and therefore nutritional requirements. Inadequate post-operative nutrition is associated with poorer outcomes and complication rates. Additionally, over feeding is also associated with adverse outcome. The actual additional energy expenditure involved in liver regeneration is not currently known and therefore accurate calorific balance remains a challenge. The measurement of energy expenditure in these patients is therefore important. Traditionally energy expenditure has been measured by indirect calorimetry and doubly labelled water. These techniques require skilled operators and are often impractical for everyday clinical usage and impossible in the deployed setting. A recent development is a lightweight armband that measures total and resting energy expenditure. It has been validated against the gold standard techniques in various settings including cancer cachexia, obesity and healthy volunteers and is deemed highly acceptable also. It has not been validated in the unique setting of liver regeneration. Therefore this study will assess the energy expenditure in patients undergoing liver regeneration and attempt to validate a new minimally invasive device against the traditional measurements of energy expenditure.
Interventions
OTHERObservational study: Sense Wear armband and indirect calorimetry used to measure resting energy expenditure
Observational methods of measuring resting energy expenditure
Sponsors
Royal College of Surgeons of Edinburgh
University of Edinburgh
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Patients undergoing liver resection for benign or malignant hepatic neoplasm
Exclusion criteria
* Inability to give written, informed consent. * Jaundice (Bilirubin \> 100 μmol/L) * Liver resection combined with secondary surgical procedure. * Age \< 18 years * Pregnant women * Unable to tolerate either measuring device
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Resting Energy Expenditure (Kcal) following liver resection | 2 weeks pre-operatively and post-operative days 3,5 and 7 |
Secondary
| Measure | Time frame |
|---|---|
| Change in total energy expenditure (Kcal) following liver resection | 2 weeks pre-operatively and post-operative days 3,5 and 7 |
Other
| Measure | Time frame |
|---|---|
| Volume of liver resected (g) | Post operative day 1 |
| Resting energy expenditure (REE) (Kcal) | 4 weeks post-operative |
| Post-operative blood tests (FBC, U&E, LFT, Coag) | Post-operative days 1-7 |
| Complications | Day of surgery and post-operative days 1-30 |
Countries
United Kingdom
Outcome results
None listed