Pre- and Postoperative Analgesia, Renal Cell Carcinoma, Spinal Anesthesia
Conditions
Keywords
Spinal anesthesia, Epidural anesthesia, Klonidin, renal cell carcinoma
Brief summary
The study aim to study whether spinal anesthesia (using: bupivacain, morfin och klonidin) can be better than epidural anesthesia during and after open surgery for renal cell carcinoma. Per- and postoperative pain after spinal anesthesia with klonidin can be reduced and, thus, shorten the hospital stay and rehabilitation of the patients.
Interventions
DRUGklonidin
spinal injection of 12 mg bupivacain,160 ug morfin och klonidin, according to age
DRUGepidural anesthesia
epidural anesthesia: patients get an continuous infusion of a solution with bupivacain 1 mg/ml, fentanyl 1 ug/ml and adrenalin 1 ug/ml
Sponsors
University Hospital, Umeå
Umeå University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* all patients in ASA score I - III, planned to be treated with open radical nephrectomy or nephron-sparing surgery having renal cell carcinoma
Exclusion criteria
* patients in ASA score IV-V, * patients with advanced tumour thrombus in vena cava inferior, * patients with high risk for bleeding * patients with previous chronic pain symptoms * patients having drug abuse * patients having cognitive deficiencies or dementia disease * patients with any contraindication of either spinal or epidural anesthesia * patients younger than 18 years and pregnant woman * patients having a weight less than 45 kg or weight over 120 kg
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative mobilisation index | within the first 30 days (plus or minus 5 days) after surgery | Using a number of variables an index of mobilisation has been created; eg pain (10 graded scale), malaise, intravenous substitution, eating in dining room, Walking outside ward room, passage of stool, carrying urinary bladder catheter, can mobilise out of bed without help |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time of hospitalization | within the first 15 days after surgery | time in hospital after surgery until discharge |
Other
| Measure | Time frame | Description |
|---|---|---|
| Need of rescue analgetics | within the first 15 days after surgery | the total amount of analgetics used besides the spinal infusion or the epidural infusion used |
Countries
Sweden
Outcome results
None listed