Estimation of Pulmonary Vascular Resistance by Contrast Echocardiography

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02028299

Enrollment

Registered

2014-01-07

Start date

2010-04-30

Completion date

2012-07-31

Last updated

2014-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Arterial Hypertension

Keywords

Pulmonary Arterial Hypertension, Pulmonary Vascular Resistance, Right Heart Catheterization

Brief summary

An echocardiogram using Definity contrast can provide the same information as the standard right heart catheterization.

Interventions

PROCEDURE2D doppler echo with Definity solution

Correlate right heart catheterization results with results from 2D doppler echo with Definity Solution

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients scheduled to undergo right heart catheterization at the George Washington University Hospital

Exclusion criteria

* Patients with known or suspected right-to-left bi-directional or transient right-to-left shunts or pulmonary arteriovenous malformations, previously documented moderate to severe tricuspid regurgitation or moderate to severe pulmonary regurgitation, evidence of right ventricular hypokinesis, or prior adverse reaction to Definity or hypersensitivity to perflutren

Design outcomes

Primary

Measure	Time frame	Description
Measure Pulmonary Vascular Resistance using 2D Doppler Echocardiogram w/Definity Solution	Two Years	Correlation coefficients between the technique above the the gold standard right heart catheterization measures of pulmonary vascular resistance.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026