Diabetes Mellitus Type II
Conditions
Keywords
Pulse walve arrival time differences
Brief summary
Vascular damage caused by diabetes mellitus, cigarette smoking, age and arterial hypertension theoretically changes pulse wave velocity.
Detailed description
Diabetes mellitus related vascular alterations are associated with an increased risk of hypertonia, atherosclerosis, neuropathy, diabetic retinopathy, and further more. Increased vascular rigidity, which is based on the increased stiffness of vessels caused by vascular damage leads to an increase of pulse wave velocity. This assumption is based on the Moens-Korteweg-equation which is calculated using the modus of arterial vessel elasticity, arterial vessel wall thickness, the arterial radius and blood viscosity.
Interventions
None listed
Sponsors
Medical University of Vienna
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients over 18 years
Exclusion criteria
* Diabetic foot gangrene * No possibility of pulse wave velocitiy measurement on the finger or toe
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulse wave arrival time difference between finger and toe, duration of diabetes | 1 Minute data recording of the pulse waves at four sites. | The pulse wave is recorded by plethysmography using a pulse-oximeter and a continuous noninvasive arterial blood pressure measurement (CNAP-500) device, both on the finger and toe. The time between these 4 recorded waves is then calculated. The influence of age, duration of known arterial hypertension, cigarette smoking (pack-years) and diabetes mellitus. |
Countries
Austria
Outcome results
None listed