Prematurity
Conditions
Keywords
infant, premature, infant, newborn, choline
Brief summary
To study concentrations of choline, its metabolites, and phospholipids in cord blood and remnants of clinically indicated blood samples
Detailed description
To collect cord plasma in preterm and term infants. To collect remnants of clinically indicated blood samples in parturients and hospitalized preterm infants during neonatal intensive care. To determine concentrations of choline, its metabolites, and phospholipids by mass spectrometry. To compare cord plasma concentrations with postnatal plasma concentrations.
Interventions
OTHERcollection of remnant of clinically indicated blood sample
collection of remnant of clinically indicated blood sample
Sponsors
Universität Tübingen
University Hospital Tuebingen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Months
Healthy volunteers
Yes
Inclusion criteria
* meeting criteria of the 4 cohorts
Exclusion criteria
* none pre-defined
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of choline in plasma | at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants) |
Secondary
| Measure | Time frame |
|---|---|
| concentrations of choline metabolites | at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants) |
| Concentrations of molecular species of phosphatidylcholine and phosphatidylethanolamine | at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants) |
Countries
Germany
Outcome results
None listed