Closed Fractures, Infection
Conditions
Brief summary
The purpose of this study is to compare the incidence rate of infection in surgical patients with closed fractures treated prophylactically with Cefazolin versus Vancomycin in the peri-operative period. The hypothesis of this study is that patients undergoing surgical treatment for closed fractures who are treated prophylactically with Vancomycin will have a lower incidence rate of infection than patients who are treated prophylactically with Cefazolin.
Interventions
DRUGCefazolin
DRUGVancomycin
Sponsors
University of Tennessee
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Between 18 years old and 85 years old * Closed fracture * Fracture treatment plan is for one operation on one day (one surgical setting) * Likely to follow-up with surgeon until fracture is healed * Ability to understand and agree to Informed Consent
Exclusion criteria
* Under 18 years old or over 85 years old * Open fracture(s) * Fracture requires multiple operations * Other injuries requiring operations * Documented allergy to Cefazolin or Vancomycin * Previous history of Methicillin-resistant Staphylococcus aureus infection * Previous surgery on the injured extremity within 1 year * Use of antibiotics within 2 weeks before or after injury * Use of antibiotics within 2 weeks before surgery * Unlikely to follow-up until fracture is healed * Unable to understand and agree to Informed Consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of infection | one year |
Countries
United States
Outcome results
None listed