Spinal Cord Injury
Conditions
Keywords
spinal cord injury, autologous bone marrow mononuclear cells, stem cell therapy
Brief summary
The aim of this study was to study the effect of stem cell therapy on common symptoms of spinal cord injury patients.
Detailed description
Autologous bone marrow mononuclear cells are administered intrathecally by a standard procedure followed by standard rehabilitation therapy.
Interventions
Bone marrow is aspirated by a standard procedure. Mononuclear cells are separated by density gradient method and then injected intrathecally by a standard lumbar puncture procedure
Sponsors
Neurogen Brain and Spine Institute
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
8 Months to 63 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed cases of any type of chronic Spinal cord injury * Age above 6 months
Exclusion criteria
* presence of acute infections such as Human immunodeficiency virus/ Hepatitis B Virus/ Hepatitis C Virus * malignancies * bleeding tendencies * pneumonia * renal failure * severe liver dysfunction * severe anemia \[Hemoglobin \< 8\] * any bone marrow disorder * other acute medical conditions such as respiratory infection * pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in clinical symptoms | 6 months | clinical symptoms were assessed based on the observation of the experts |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional Independence Measure (FIM) | 6 months | Functional Independence Measure (FIM) is a standard scale performed before and 6 months after the intervention to measure the functional ability of the patients. |
Countries
India
Outcome results
None listed