Major Depressive Disorder
Conditions
Keywords
major depressive disorder, cerebrovascular reactivity, emotional reactivity
Brief summary
The main objective is to compare the physiological reactivity (heart and respiratory rates, galvanic skin response, cerebral perfusion, and startle) in the three phases of emotion between depressive subjects, subjects remitted from depression and control subjects.
Interventions
BEHAVIORALpsychometric tests
NEO-PI, MADRS, MINI depression, MMSE, STAI-E, ERD, Anhedonia
DEVICEMRI
ASL, rest f-MRI, FLAIR, white matter hyper intensities load
DEVICEtranscranial doppler and TPI
transcranial doppler TPI
BEHAVIORALexplicitative interview
Sponsors
University Hospital, Tours
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Female between 18 and 55 * Informed consent form signed * Affiliated to a medical insurance * visual and hearing abilities suitable for exams * for the depressive group (group D): major depressive disorder according to the DSM-IV criteria as evaluated by the MINI test and MADRS score ≥22 * for the depressive patients in remission's group (group R) : matched on age, at least 1 history of major depressive disorder in the last 10 years and solved for more than 6 months, and MADRS score \< 9 * for the control subjects (group T) : matched on age, no psychiatric history, MADRS score \< 9
Exclusion criteria
* psychotic disorder, bipolar disorder, addiction, suspected dementia (MMSE\<25) * current betablockers or neuroleptics treatment * any current organic unstable pathology * history of serious cardiovascular disease (coronary syndrome, cardiac arrythmia, etc.) * smoking \> 10 PY * history of serious neurologic disease (stroke, cerebral tumour, serious cranial trauma, headache, ...) * contra-indication to MRI * uncorrected vision or audition troubles * patient under juridic protection * pregnancy, lactating or female without reliable contraception
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| amplitude variations of heart and respiratory rate, cerebral pulsatility, galvanic skin response and startle as measure of physiological reactivity | one day | amplitude variations of heart and respiratory rate, cerebral pulsatility, galvanic skin response and startle. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MRI data as measure of cerebral perfusion, volume of leukoaraiosis and default network (fMRI at rest) | one day | cerebral perfusion measured by MRI (Arterial Spin Labelling) volume of leukoaraiosis default network (fMRI at rest) |
| ultrasound data of doppler as measure of cerebral pulstility | one day | doppler index of middle cerebral artery At the same time, heart rate variability and cerebral pulsatility at rest will be collected |
| score of psychometric tests as measure of emotional state | one day | MADRS score, ERD score, STAI-E score, anhedonia score, Neo-PI score, and the subjective assessment of emotional arousal (self Manikin assessment). |
| spontaneous verbal production to emotional pictures and explicitative interviews | one day | spontaneous verbal production to emotional pictures and explicitative interviews |
Countries
France
Outcome results
None listed