SpareBrain - Mechanisms and Prevention of Secondary Brain Injury in Subarachnoid Haemorrhage

Conditions

Aneurysmal Subarachnoid Hemorrhage

Keywords

subrachnoid hemorrhage, secondary brain injury

Brief summary

Subarachnoidal hemorrhage (SAH) is a cause of long-term disability and death. Annually about 1000 people in Finland suffer from SAH, their average age being under 50 years. SAH has a mortality rate of 12 % acutely and 40 % of patients die within a month from admission to hospital. In addition, 30 % of the surviving patients remain with neurological deficits. Most survivors of the primary insult suffer from secondary injury during the first 2-3 weeks from the insult. Despite the advances in neurosurgical and -radiological techniques and intensive care, the mortality and morbidity rates in SAH have not changed in recent years. There is still only limited understanding of the mechanisms of secondary insults causing brain injury after SAH. In this study the investigators are aiming to clarify the timescale and mechanisms contributing to the secondary insults. The investigators also explore usability of novel biomarkers to guide treatment of the patients suffering from SAH.

Detailed description

Subarachnoidal hemorrhage (SAH) is a cause of long-term disability and death. Annually about 1000 people in Finland suffer from SAH, their average age being under 50 years. SAH has a mortality rate of 12 % acutely and 40 % of patients die within a month from admission to hospital. In addition, 30 % of the surviving patients remain with neurological deficits. Most survivors of the primary insult suffer from secondary injury during the first 2-3 weeks from the insult. Despite the advances in neurosurgical and -radiological techniques and intensive care, the mortality and morbidity rates in SAH have not changed in recent years. There is still only limited understanding of the mechanisms of secondary insults causing brain injury after SAH. In this study the investigators are aiming to clarify the timescale and mechanisms contributing to the secondary insults. The investigators also explore usability of novel biomarkers to guide treatment of the patients suffering from SAH.

Related papers

No related papers found yet.

Interventions

PROCEDUREMagnetic resonance imaging

PROCEDURECerebral microdialysis catheter insertion

Is inserted only when invasive intracranial pressure monitoring is required. The same route with pressure probe is used for insertion.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* aneurysmal subarachnoid haemorrhage

Exclusion criteria

* age under 18 years * pregnant * moribund patient

Design outcomes

Primary

Measure	Time frame	Description
Neuroradiologically confirmed secondary injury lesions	up to 2 weeks after the primary insult	Neuroradiological imaging (CT/MRI) is performed when clinically indicated and at 2 weeks after primary insult.

Secondary

Measure	Time frame	Description
Neurological outcome of the patient	6 months	Neurological outcome is evaluated with modified Rankin Scale at 6 months.

Countries

Finland

Outcome results

None listed