Pulmonary Hypertension
Conditions
Brief summary
The diagnosis of a patient with pulmonary hypertension (PH) requires many investigations. At present cardiac catheterisation is the cornerstone investigation in these patients where it is used to establish disease severity and estimate prognosis. It is an invasive procedure which is expensive and not without risk to the patient. Despite the multitude of tests performed, identifying those patients with PH who have a poor diagnosis can be difficult. The aim of this study is to improve the assessment of patients with PH using novel magnetic resonance techniques.
Interventions
OTHER3-Helium gas
3-Helium gas for MRI contrast
Sponsors
University of Sheffield
Sheffield Teaching Hospitals NHS Foundation Trust
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All cases referred to the clinic for assessment for possible pulmonary hypertension.
Exclusion criteria
* patients with a cardiac pacemaker or retained temporary pacing wire * patients with aneurysm clip * non MRI compatible heart valve prosthesis * intra orbital metalic foreign body * pregnancy * metal prosthesis/spinal rods * retained shrapnel * cochlear implants/bladder stimulator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pulmonary artery diameter (mm) | up to 3 months | Three-dimensional MRI imaging will be used to acquire cardiac dimensions and anatomical ventilation distribution as well as regional partial pressures of oxygen in the lungs. |
Countries
United Kingdom
Outcome results
None listed