Chalazion
Conditions
Keywords
Size, Pain, Resolution, Complications, Swelling
Brief summary
Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.
Detailed description
This is a prospective randomized interventional study comparing four current standard-of-care treatments for chalazia: incision and curettage, local injection of triamcinolone, local injection of 5-FU, and local injection of combination triamcinolone/5-FU.
Interventions
If the chalazion is present at follow-up visit, another injection of 5-FU will be given.
DRUGTriamcinolone Acetonide
If chalazion present at follow-up, another Triamcinolone injection will be done.
PROCEDUREIncision and Curettage
If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.
DRUGTriamcinolone Acetonide/5-fluorouracil mixture
If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.
Sponsors
University of Washington
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Single or multiple chalazia in a single eyelid
Exclusion criteria
* Chalazia present for less than one month and no previous injection or incision and curettage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Size of chalazion | 4 weeks |
Countries
United States
Contacts
Primary ContactSimona Vuletic
Backup ContactIan Luttrell
Outcome results
None listed