Morbid Obesity
Conditions
Keywords
Bariatric Surgery, Obesity, Metabolic syndrome, Diabetes, Liver Disease
Brief summary
Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.
Detailed description
Study participation by invitation after complete pre-surgical work up at UC Davis Health System. Patients will be invited to participate if they meet all inclusion criteria's after completing all necessary clinical visits including lab studies, counseling, and participation in educational programs. During the pre-operative visit patients interested in participation will complete all necessary consent documentation. Pre-operative labs (blood and urine) will be collected along with additional blood, urine, and fecal samples will be collected pre-operatively. During surgery (Roux-en-Y Gastric Bypass surgeries only) tissue collection will include subcutaneous & omental fat, jejunum, and liver biopsy. Post surgery patient will be observed for weight loss and resolution of co-morbidities. At designated times post surgery when lab studies are ordered additional blood/urine samples will be collected and analyzed.
Interventions
OTHERSurgery
Patients wishing to participate in the research will complete all necessary pre-operative work-up labs, testing \& counseling, complete and sign the informed consent. During weight loss surgery a small amount of subcutaneous and omental fat will be collected for analysis, with subsequent blood collection post surgery for analysis.
Sponsors
University of California, Davis
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Meet NIH Criteria for Bariatric Surgery * Between the Age of 18-55 * Dyslipidemia controlled with medication * Impaired glucose metabolism or type 2 diabetes
Exclusion criteria
* Uncontrolled Metabolic syndrome (uncontrolled diabetes, htn, dyslipidemia), one or all conditions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tensile Strength of White Adipose Tissue | July 2012 | During the research tissue samples were compared between healthy obese patients (no diabetes, controlled HTN, no dyslipidemia) with tissue samples collected on non-healthy obese patients (type II diabetes) and using fat collected from mice as a control. |
Countries
United States
Contacts
CONTACTMohamed R Ali, MD
CONTACTWilliam H Smith, BS, CCRP
PRINCIPAL_INVESTIGATORMohamed R Ali, MD
University of California Davis Health System
Outcome results
None listed