Childhood Obesity, Hypercholesterolemia, Hypertension, Type 2 Diabetes
Conditions
Keywords
Pediatric Overweight/Obesity, DEXA, Fitness
Brief summary
This project will address the important area of childhood obesity and the risk of cardiovascular disease associated with obesity. This is a serious health concern since children who are overweight or obese are prone to other medical conditions including high blood pressure, abnormal lipid profiles,and type 2 diabetes. Although exercise and nutrition programs are recommended, evidence for the efficacy of these programs in improving cardiovascular health is lacking. Specific Aims: a) improve cardiovascular risk factors, b) increase physical fitness levels, c) improve lean body mass, d) enhance QOL of the child e) influence adherence rates to exercise and a healthy lifestyle change both during and beyond the conclusion of the program. Hypothesis 1a: Compared to baseline and matched controls, children randomized to a 10 week multidisciplinary fitness and nutrition program will show significant improved levels of cardiovascular risk factors. Specific Aim 2: To determine if a multidisciplinary fitness and nutrition program, when compared with a matched, WLC group will show a change in whole body assessment including a decrease in fat mass, an increase in percent lean body mass, and a decrease in percent body fat, as measured utilizing dual-energy X-ray absorptiometry Hypothesis 2a: Compared to baseline and matched controls, children randomized to a 10 week multidisciplinary fitness and nutrition program will show improved whole body assessments including. Specific Aim 3:To determine if a multidisciplinary fitness and nutrition program, when compared with a WLC group will show improved levels of fitness. Hypothesis 3a: Compared to baseline and matched controls, children randomized to a 10 week multidisciplinary fitness and nutrition program will show significant improvements in fitness including.
Interventions
OTHERExercise
Strength training, aerobic exercise and core strengthening, running
Sponsors
Stony Brook University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
8 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* : a) in the 85th percentile Body Mass Index(BMI), standardized for age and gender; b) have hypercholesterolemia as defined as total cholesterol \> 170 mg/dl or LDL \> 110 mg/dl; and / or c) hypertension as defined as \>116/76 for 8-10 year olds, \> 120/80 for 10-13 year olds, and \>125/890 for 14-17 year olds.
Exclusion criteria
* 1\) age \< 8 or \> 17 years; 2) the determination of significant abnormalities on an initial graded exercise test performed by a pediatric cardiologist; 3) past history of chemotherapy or whole-body radiation therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improved body compositon (decrease in % fat; increase in % lean tissue) using DEXA | Baseline, after 10 weeks and after 20 weeks (3 time points) | Dual energy x-ray absorptiometry - used to assess body composition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improved levels of fitness using ACSM guidelines / assessments to measure such constructs of fitness as flexibility, muscle strength, cardiovascular endurance and agility. | Measured at baseline, after 10 week sand again after 20 weeks. | ACSM guidelines and measurement were used to assess strength, agility, flexibility, muscle endurance and cardiovascular endurance |
Other
| Measure | Time frame | Description |
|---|---|---|
| Quality of life as perceived by the children and the parents. | Baseline and after 10 weeks and 20 weeks. | The impact of weight on quality of life was utilized. |
Countries
United States
Outcome results
None listed