Single Dose of Atorvastatin and Circulating Endothelial Microparticles

The Effect of Single Dose of Atorvastatin on Change of Circulating Endothelial Microparticles

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02023892

Enrollment

Registered

2013-12-30

Start date

2014-06-30

Completion date

Unknown

Last updated

2014-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelium, Hydroxymethylglutaryl-CoA Reductase Inhibitors

Brief summary

Healthy subjects take single dose of 80mg atorvastatin, then measured their circulating endothelial microparticles and flow-mediated vasodilation in the brachial artery by ultrasound at different time points.

Interventions

DRUGatorvastatin

DRUGplacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy youth

Exclusion criteria

* acute pathologies * familial history of cardiovascular disease * smoking or drinking alcohol

Design outcomes

Primary

Measure	Time frame
change of circulating endothelial microparticles	from 1h to 24h after taking atorvastatin

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026