Mild Cognitive Impairment
Conditions
Keywords
lutein, cognition, neural efficiency, aging
Brief summary
Past research suggests that retinal lutein levels are related to cognitive function as measured via behavioral tests. The goal of the present study is to investigate the relationship between lutein and cognitive function in a wider variety of the population (young, healthy adults and older adults), using a wider variety of methods (behavioral testing and neuroimaging).
Detailed description
Past research suggests that retinal lutein levels are related to cognitive function as measured via behavioral tests. The goal of the present study is to investigate the relationship between lutein and cognitive function in a wider variety of the population (young, healthy adults and older adults), using a wider variety of methods (behavioral testing and neuroimaging).
Interventions
DIETARY_SUPPLEMENTactive supplement
tablet
OTHERplacebo
tablet
Sponsors
Abbott Nutrition
DSM Nutritional Products, Inc.
University of Georgia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* visual acuity correctable to 20:40 or better, Snellen notation * able to swallow a dietary supplement * free of dementia, characterized by a score of less than 1.5 on the Clinical Dementia Rating Scale
Exclusion criteria
* GI conditions that interfere with lipid absorption * presence of or past diagnosis of age-related macular degeneration * visual acuity poorer than 20:40, Snellen notation * has taken lutein, omega-3 fatty acid or fish oil supplements within the last 6 months * presence of dementia, characterized by a score of 1.5 or greater on the Clinical Dementia Rating Scale
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| macular pigment optical density | 12 months | optical density of macular pigment layer in central retina, defined in log units of optical density |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| serum carotenoid levels | 12 months | serum carotenoids will be measured via high performance liquid chromatography |
| reaction time | 12-months | reaction (msec) to a light stimulus |
| executive function | 12-months | computerized composite score from computerized battery |
| short-term memory | 12-months | composite score from a computerized battery |
| visual attention | 12-months | composite score from computerized battery |
Countries
United States
Outcome results
None listed