Branched Chain Aminoacid Supplementation in Patients With Liver Cirrhosis

High-fiber High-fiber Diet and Branched Chain Aminoacids. Impact on Nutritional Status and Complications in Patients With Liver Cirrhosis

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02023229

Enrollment

Registered

2013-12-30

Start date

2011-01-31

Completion date

2013-05-31

Last updated

2013-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cirrhosis

Keywords

Branched chain aminoacids, Nutritional status, Hepatic encephalopathy

Brief summary

Malnutrition is a frequent complication in patients with liver cirrhosis. Most patients have decreased dietary intake due to ascites, hepatic encephalopathy and pro-inflammatory cytokines. We hypothesized that branched chain aminoacids can improve nutritional status and delay episodes of hepatic encephalopathy

Interventions

DIETARY_SUPPLEMENTBranched-chain aminoacids

OTHERHigh-fiber high protein diet

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

Ambulatory patients Patients with confirmed diagnose of liver cirrhosis Patients classified as Child-Pugh A or Child Pugh B

Exclusion criteria

Acute or chronic renal failure Pregnancy Overt hepatic encephalopathy

Design outcomes

Primary

Measure	Time frame	Description
Nutritional status	At time of recruitment	Assessed by bioelectrical impedance vector analysis and mid-arm muscle circumference

Secondary

Measure	Time frame
Hepatic Encephalopathy	At time of recruitment

Other

Measure	Time frame	Description
Nutritional status	3 months follow-up	Assessed by bioelectrical impedance vector analysis and mid-arm muscle circumference
Hepatic encephalopathy	6 months follow-up	—

Countries

Mexico

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026