Resting Metabolic Rate
Conditions
Keywords
Nitrate, Nitrite, Nitric oxide, Resting metabolic rate, Glucose uptake, Insulin sensitivity, Reactive oxygen species production, inorganic nitrate, Sodium nitrite infusion
Brief summary
The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.
Interventions
OTHERGlucose Uptake
Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp
OTHERResting metabolic rate
Resting metabolic rate is measured by indirect calorimetry after an over-night fast
OTHERNitrite infusion
Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion
Sponsors
The Swedish Research Council
Swedish Heart Lung Foundation
Karolinska Institutet
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy volunteers
Exclusion criteria
Chronic medication Vegetarian Nicotine Users Known metabolic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Resting metabolic rate | day 4 | Resting metabolic rate, measured after overnight fast using indirect calorimetry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thyroid hormone status | day 4 | — |
| Glucose uptake | day 4 | Glucose uptake measured with oral glucose tolerance test and euglycemic clamp |
| Nitrite infusion | 30 minutes | Effect on resting metabolic rate when infusing escalating intravenous doses of sodium nitrite or saline solution |
Countries
Sweden
Outcome results
None listed