Nocturnal Alveolar Hypoventilation, Obesity-hypoventilation Syndrome
Conditions
Keywords
OHS
Brief summary
Investigate whether the course of an isolated nocturnal alveolar hypoventilation can predict the future occurrence of obesity-hypoventilation syndrome (OHS) in obese subjects
Interventions
OTHERAnnual visits among 3 years. During each visit different testings are performed in order to detect an obesity-hypoventilation syndrome (OHS)
Polygraphy/Polysomnography,Blood sampling, EKG,Lung function testing,Arterial blood gases,Thoracic radiography,Six-minute walk test,Respiratory questionnaires
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Obese volunteer Subject (BMI\> 30 kg/m2) * Adults of either sex * Social security affiliation * Written informed consent
Exclusion criteria
* Confirmed OHS at baseline defined by a daytime hypercapnia with PaCO2\> 45mmHg * Any cause of chronic respiratory failure other than obesity such as COPD, chest deformation, phrenic nerve paralysis, pulmonary fibrosis, neuromuscular disease, a history of mutilating thoracic surgery ... * Obstructive ventilatory defect with FEV1/ FVC \<70% post-bronchodilator * Long term oxygen therapy, noninvasive ventilation, continuous positive airway pressure * Any serious illness involving life-threatening within 3 years after inclusion * Drug or alcohol abuse * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of obesity-hypoventilation syndrome | 3 years | partial pressure of carbon dioxide in the arterial blood \> 45mmHg |
Countries
France
Outcome results
None listed