Cerebral Microembolism During Hemodialysis

Quantity, Quality and Laterality of Cerebral Microembolism During Veno-Venous Hemodialysis.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02021045

Enrollment

Registered

2013-12-27

Start date

2013-09-30

Completion date

2016-03-31

Last updated

2016-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Embolism, Complication of Dialysis, Thrombus Due to Renal Dialysis Device, Implant, or Graft

Brief summary

There is increasing evidence that renal replacement therapy (= continuous veno-venous hemodialysis) generates cerebral microembolism which is detectable on transcranial Doppler ultrasound. The aim of this study is to monitor patients with transcranial Doppler under two conditions: during hemodialysis and in a hemodialysis-free interval (in each period cerebral embolic load is detected during 30 minutes). The study hypothesis is that during hemodialysis the cerebral embolic load is significantly higher than in the hemodialysis-free interval.

Interventions

DEVICERenal hemodialysis (Fresenius 2008K, Bad Homburg, Germany)

Renal replacement therapy is frequently used in patients with renal failure in order to eliminate substances obligatory excreted by the urine.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Renal replacement therapy (continuous veno-venous hemodilalysis) on the in-house intensive care unit * Age \> 18yrs and \< 90yrs

Exclusion criteria

* Absent informed consent * Preexistent neurological morbidity * Neurocognitive disturbances * Carotid artery stenosis \> 70% * Patent foramen ovale * Treatment with other extracorporeal devices * Cardial pathology (valvular heart disease, prosthesis, endocarditis) * Pregnancy, drug abuse * Inclusion in an other clinical study * Allergy against materials of the medical device used in the study (transcranial Doppler) or temporal skin/bone lesions

Design outcomes

Primary

Measure	Time frame	Description
Quantity of cerebral embolic load	30 minutes	Cerebral embolic load is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.

Secondary

Measure	Time frame	Description
Quality and laterality of cerebral embolic load	30 minutes	Quality (solid vs. gaseous) and laterality (left vs. right hemispheric dominance) of cerebral embolic load is measured in a 30 minutes-interval during hemodialysis and in a hemodialysis-free interval.

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026